Guardiola said it is "incredible" to have four English clubs in the quarter-finals after a decade of Spanish control which saw the country provide three of the last eight for six successive seasons until this campaign.
On that occasion, Chelsea beat Liverpool to reach the last four, before losing to eventual winners Barcelona in the semis, while Manchester United and Arsenal emerged from their quarterfinals to meet in the last four, with United prevailing before losing to Barca in the final.
Liverpool can return to the top of the Premier League with a win at Fulham on Saturday.
United's unexpected victory over PSG also ensures that they will be regarded as a unsafe outsider in Friday's draw, but while it's inevitable that the focus will be on the prospect of a first English Champions League victor this season since Chelsea in 2012, it would be wise to consider the threat posed by Messi and Ronaldo, with Barca and Juve respectively, to Premier League ambitions.
Spurs made it through to the quarter-finals with a stunning 4-0 victory over Borussia Dortmund on aggregate.More news: Manhattan DA announces state fraud charges against Manafort
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"They deserve to be there and we know they will be tough teams".
"Let's say if two of our teams made it to the Champions League final, then we wouldn't see them, at best, until the Monday before we play on the Thursday".
There could also be another fixture reversal for Ole Gunnar Solskjaer's team if both United and City progress through to the semifinal stage of the competition.
They have also played twice in European knockout stages and, while Porto eliminated the Blaugrana in 1972/73, the 1985/86 tie had the opposite result.
"They would rather be in this position now where they have got something to fight for every single game than a mediocre side, they are not that".