The former Harpenden St George's pupil went down in the 54th minute of the 2019 Guinness Six Nations clash in Dublin following a ruck, prompting referee Jerome Garces to say at the time "I think he's broken his leg".
Sarries team-mate Nick Isiekwe has been called up in Itoje's place, while uncapped quartet Jack Singleton, Ben Earl, Dan Robson and Ollie Thorley are part of the squad.
Ireland started the defense of their Six Nations title at Dublin's Aviva Stadium as the world's form team, but were brought down to earth with a startling bump.
The best example of England's successful deployment of the kick in attack came in the second-half try that pushed them out of Ireland's reach when Henry Slade sprinted on to May's chip and touched down.
It was also England's first success across the Irish Sea in six years and yet worryingly for the rest of the championship, Jones felt there was still plenty more in the tank. "I absolutely hate it", Ward said on the BBC Sport website.More news: Haas become first Formula 1 team to unveil vehicle for 2019 season
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"Physically we know we can be up at that level, but we were just off and we've got to sort that out".
"We knew we had to win that battle to win the game".
With Italy away to come next the game with England in Cardiff is not surprisingly the hottest ticket in town right now and Wales shouldn't be underestimated as they look to upset the odds and topple a much fancied England side. We were just a little bit off.
"They accepted nothing from us and gave us as little as possible and that's a credit to them". I didn't see Daly out there, I thought it was May. "I don't think that has changed in one game". "I am a fully signed-up member of the low-key, respectful Schmidt approach every time and I qualify that by saying that what goes on behind closed doors at in-house meetings is very different to that dished out at PR-perfect press conferences for public consumption".
Even though this was just the opening round of the championship, it was hard not to look beyond it and to the World Cup in Japan in September and October.
Ireland move swiftly on to face Scotland in Edinburgh on Saturday, with Murray well aware only a rapid recalibration can set Schmidt's men back to winning ways.