The Chicago area could start to see snowfall starting late Friday and going much of the day Saturday as most of IL was under winter storm warnings and advisories, with up to 9 inches of snow forecast for southwest parts of the state.
A massive winter storm hit the US Rockies and Plains on Friday then punched east, with snow set to assault a 1,800-mile (1,609 km) corridor through the weekend, creating transportation "havoc" in the middle of the country.
At Lambert International Airport in St. Louis, most flights were canceled or delayed on Saturday.
A winter storm that contributed to at least five deaths in the United States midwest was pummeling the mid-Atlantic region for a second day on Sunday, bringing snow, freezing rain and power outages.
A winter storm that contributed to at least five deaths in the Midwest is pummeling the mid-Atlantic region for a second day, bringing snow, freezing rain and power outages. Major cities in the zone, including St. Louis, could get more than 6 inches of snow.More news: Donald Trump promises changes to H-1B visa programme, including potential citizenship
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The storm hit Kansas and Missouri on Friday and pummeled those states again on Saturday as it extended into parts of Iowa, Illinois, Indiana and OH, said U.S. Weather Prediction Center meteorologist Andrew Orrison.
In a tweet Saturday morning, the patrol said it also had responded to 48 injuries, 723 crashes, 1,252 stranded motorists and 2,968 calls for service.
Cole County Public Works Director Larry Benz said the forecast the county used estimated Mid-Missouri could receive up to 15 inches of snow.
A few major East Coast cities are likely to see some impact, including Washington, Baltimore and Philadelphia, and there is a possibility for light accumulation in NY along the northern edge of the storm. It would be among the city's 10 greatest snowstorms - landing at the No. 2 spot - of all time if that happens. The Missouri Department of Transportation had 219 snow plows, sand and salt trucks in their central district trying to keep major arteries like USA 54, US 63 and Interstate 70 clear, said Paul Dinkler, MoDOT assistant maintenance engineer for the central district. Half an inch of ice and 3 to 5 inches of snow are predicted.
On the storm's southside, more heavy rain will fall on the already saturated South. The wintry mix was also causing problems at airports in the region, including more than 250 flight cancellations at the three main airports serving the nation's capital.
The University of Missouri men's basketball game at the University of SC was also canceled Saturday because of weather-related travel issues, according to the team's Twitter account.