The estimated jackpot ahead of the draw is $321 million.
The lucky numbers are 2, 8, 42, 43, 50 and Mega ball 6. That comes out to a cash option of $193.7 million.
The next Mega Millions drawing will be held Friday at 11 p.m.
Mega Millions winning numbers: Are you the lucky victor?
"Each state uses its unclaimed lottery prizes for different purposes", the Mega Millions' website explains.More news: What Is the Nickname Kate Middleton Calls Prince George and Princess Charlotte?
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The winning ticket was sold in the town of Simpsonville, lottery officials said.
The jackpot for Mega Millions now stands at about 321 million dollars, and 294 million for Powerball. Timothy Monte of Tohajiilee, New Mexico, claimed his winnings of $4 million on Tuesday, December 18.
According to the Mega Millions your overall chances of winning a prize are 1 in 24.
Monte said he only plays Mega Millions and thought he had won $40,000 from the drawing, but he won $4 million.
The grand prize has grown to $321 million after a nine-week spell without a victor. The victor has a total of 180 days to claim the money, according to state law, and the countdown starts from when the winning numbers were announced.