After winning the toss, Windies skipper Jason holder chose to bat first and soon his decision backfired as the home team bundled the visitor for 104 runs.
India's ODI dominance started in South Africa as Kohli and boys shrugged off the disappointment of the Test series. West Indies will try its best to level the series while India would like to win and wrap up the series.
After left-hand batsman Shikhar Dhawan was dismissed cheaply for six, Indian opener Rohit Sharma (63) and skipper Virat Kohli (33) stitched a match-winning partnership of 99 runs to drive their side to a comfortable victory. By the tenth ball of their innings, Bhuvneshwar Kumar, swinging it away from the left-hander, and Jasprit Bumrah, swinging it into the right-hander, had made Kieran Powell and Shai Hope pay for playing away from the body.
So promising across the first three ODIs, West Indies' batting unravelled when a share of the series was still up for grabs.
The experienced Marlon Samuels, from whom a lot was expected, led a brief revival, hitting some crisp boundaries and the only six of the innings. "It won't happen all the time, but when I'm going, I want to keep going longer", said Kohli.
There was a lot of praise for the Windies batsmen from their captain Jason Holder after the first three ODIs, as they comfortably scored above 250 and gave their bowlers decent totals to defend.More news: South Korea court orders Japan's Nippon Steel to compensate forced laborers
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Left-arm spinner Ravindra Jadeja took four wickets to help India bundle out the tourists for 104 in just 31.5 overs.
Along with another T20 stalwart Kieron Pollard and five others, Brathwaite trained hard with the first T20 global against India starting November 4.
RESULT: India won by nine wickets to win five-match 3-1.
MATCH REFEREE: B.C. Broad (England).
FIRST MATCH: Guwahati, India won by eight wickets.
Sharma then fittingly ended the match with a single to long on two balls later.