Interpol says it has received the resignation of Meng Hongwei, the Chinese president of the worldwide police organization who went missing one week ago.
As well as leading the International Criminal Police Organization as president, Meng is also a Chinese politician and former official from the Communist Party of China.
On Saturday, quoting a source, Hong Kong-based South China Morning Post had reported that Meng, the first Chinese head of the worldwide law enforcement agency headquartered in France, was "taken away" for questioning by discipline authorities "as soon as he landed in China" in the last week of September. Ms Meng said he sent her an image of a knife that day, which she thought was a warning that he was in danger.
The statement was the first from China since Meng's disappearance was reported in France on Friday.
Grace Meng said he travelled to the country in September for work.
A new president will be elected for the remaining two years of Mr Meng's mandate at the general assembly in Dubai next month.
Asked if she believes he has been arrested, she said: "In China, what happened, I'm not sure".
The Central Commission for Discipline Inspection, the Chinese Communist Party's secretive internal investigation agency, had no announcements on its website about Meng and could not be reached for comment.
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Interpol announced Sunday that it had accepted the resignation of its president, Meng Hongwei, who disappeared in China in late September.
An hour earlier, Meng's wife told reporters in the French city of Lyon that she feared that her husband's life was in danger.
Two days after he was reported to have gone missing on his China visit, Interpol president Meng Hongwei has submitted his resignation to France, Interpol has said.
She kept her back turned to the reporters present, and refused to be photographed out of fear for her safety.
According to Interpol's website, Meng has almost 40 years of experience in criminal justice and policing, and has overseen matters related to legal institutions, narcotics control and counterterrorism. France launched its own investigation, with French authorities saying Meng boarded a plane and arrived in China, where the trail goes cold. Critics in China and overseas have warned that many corruption investigations are politically motivated and used to consolidate Xi's power and topple rival factions.
He appointed Meng vice security minister in 2004.
China's recently established National Supervisory Commission holds sweeping powers to investigate the country's public servants with few requirements for transparency.
Meng's vanishing act bears hallmarks of what happens to senior officials when they are suspected of violating party rules, usually alleged corruption.
The organisation's secretary general, Jürgan Stock, has demanded a "clarification" from Beijing.