United have only won one of their four matches in all competitions at Old Trafford this season - and the last time the ground hosted a Champions League game, Jose Mourinho's side were knocked out by Sevilla at the last-16 stage.
"Luke Shaw for example said "we players on the pitch have to give more".
As the visiting manager, Marcelino was asked what he thought were the best and worst aspects of Manchester United.
United are back in action on Tuesday night with a home match against Valencia in the Champions League.
Alexis Sanchez, with only three goals in 23 games since his move from Arsenal in January, was axed for Saturday's game at West Ham; Marcus Rashford has been rebuked for failing to warm down correctly after a Champions League game.
Manager, Jose Mourinho, has been quick to apportion blame for his side's struggles so far this season. This being Mourinho, you could offer half a dozen different interpretations and they may all be right. "I see upset people, some people that don't look like they lost a game".More news: Previewing Game 163 for the NL West Title
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Paul Pogba was substituted at the weekend and Alexis Sánchez dropped altogether, the Chilean reportedly furious about being taken to London and made to sit in the stands.
"They're not used to going through a hard situation, but I think that's part of the career of a footballer". Everyone is trying to do more for the team.
"He stripped Pogba of the captaincy, which I agreed with, but it sounded like it was in front of the players and the players don't want that now, they don't".
"I don't think with talking you can resolve something", Matic said. They do it, they don't do it that's a different story, but I repeat I am naive or I still believe the player is an honest man.
Offensively they have a lot of potential with players of the highest level, some costing more than 70 million who represent their countries. "A club like this, a team like this, one of the most successful coaches in the world, with a huge investment".