And with the like of former United defender Rio Ferdinad saying "something needs to give" at Old Trafford, there is a sense that Mourinho is struggling for answers and running out of time.
Sanchez's City snub led to Guardiola targeting Riyad Mahrez, who he eventually signed in the summer after a failed attempt late in the January transfer window.
"I look forward to that match on Tuesday and I hope the majority of the players have this same kind of mentality, and that they are looking forward to Tuesday".
"Everyone wants to play Champions League, not everyone can do it".
The 76-year-old is now said to be disturbed that Manchester United have now turned to a laughing stock after losing three games this season in the English top flight.
"He's direct. If he has to say something to the manager he has to talk to me", Sarri said. "So, big match, big week".
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"But it looks as if he has gone back to that, or is still doing that, at Manchester United".
Fans were left in uproar after the last Champions League night at Old Trafford when United were shocked by a 2-1 defeat to Sevilla in the round of 16 second leg that sent them crashing out of Europe last season. The game was really bad but everyone has responsibilities. Only two Spanish clubs have ever lost 5+ consecutive games in the history of the competition - Real Sociedad (five in October 2013) and Villarreal (seven in December 2011).
"He was a little confused [when I arrived] because two seasons ago he was a protagonist [in the team], and then [he went] six months without playing".
"Morata in the last 25 minutes was more aggressive than usual".
Sports analysts Gracenote say United have a 84% chance of progressing to the knockout stages, an increase of 16% from before their win over Young Boys.
While the Chilean could be an option for the Valencia game, four players have been ruled out with injury concerns by the United manager.
Jose Mourinho's men sunk to new depths of misery with an inexplicably very bad performance at the Olympic Stadium, conceding twice in the first half and immediately losing another goal right after Marcus Rashford scored to give Man United hope later in the game.