Luis Enrique got off to a ideal start as manager of Spain, as his charges came from behind to register a 2-1 win over England in a UEFA Nations League clash at Wembley Stadium.
However, Spain hit back nearly immediately through Saul Niguez and Rodrigo netted later on in the first half to give the visitors the lead.
The game opened up in the closing minutes as England pushed for an equaliser, with Rashford shooting right at De Gea after being played into the penalty area with a neat ball from Harry Kane.
England's World Cup satisfaction has been punctured by Spain on its homecoming.
The turnaround was complete for Spain on 31 minutes as Rodrigo turned home Thiago Alacantara's in-swinging free-kick at the near post.
The night had started in excellent fashion for the Three Lions when left-back Luke Shaw laid on a beautifully weighted assist for his Manchester United teammate Marcus Rashford to slot home and put England into an early lead.More news: Freeman, Neal exit opener vs. Eagles with knee injuries
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Spain's easy-on-the-eye style began to pick holes in England as the likes of Isco, Alcantara and Saul Niguez took charge.
After a slow start to the second stanza, both coaches opted for changes as England threw on Eric Dier for Jordan Henderson, while Marcos Asesnio replaced Iago Aspas for the visitors.
Shaw left the field on a stretcher after more than five minutes of medical attention.
England weathered the storm though and pressed late on for an equaliser with De Gea forced into several good saves.
"We are under no illusion that Spain were the better team for long periods".
"We aren't able to do that when teams press high against us yet".
England reached the semifinals in Russian Federation, but lost to Croatia and then fell to Belgium in the third-place game.