Both Gaston Pereiro and Steven Bergwijn fired just wide, while at the other end, Barcelona dominated possession but were restricted to only a few chances. Him and Ousmane Dembele have settled into the squad, so they should ensure there isn't as much reliance on Messi to produce moments of individual brilliance.
Coached by former Barca and Netherlands midfielder Mark van Bommel, PSV had produced an admirable performance in their first visit to the Nou Camp in 21 years until they began to tire late in the second half.
Lozano has seen his stock skyrocket since his exploits at the 2018 FIFA World Cup, where he was one of the best young players in action. He curled the ball over the PSV wall from 25m out into the top corner beyond the reach of goalkeeper Jeroen Zoet.
Speaking ahead of PSV's Champions League clash away to Barcelona on Tuesday, Lozano has spoken about his desire to play in the famous blue and red one day.More news: Maybe what is expected of Liverpool is too much - Wijnaldum
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Umtiti was sent off after a foul on PSV forward Hirving Lozano while trying to stop a breakaway.
He has now scored 104 goals in the competition and has netted in a 14th consecutive Champions League campaign - a joint record with Real Madrid legend Raul.
The two teams are in Group B with Inter Milan and Tottenham.
Three goals became four before full time thanks to Messi's clipped finish over Zoet after being played through by Suarez, maintaining Barca's flawless start and inflicting a first competitive managerial defeat on Mark van Bommel.