Chief accounting officer Dave Morton gave notice on Tuesday that he was resigning less than a month into the job, according to a filing.
Just six months ago, the gushing - largely accurate - descriptors often used for Elon Musk were nearly embarrassing in their grandeur: magnate, mogul, inventor, tycoon, engineer, genius, visionary, space pioneer, revolutionary.
Morton's departure further roiled the company, which has been under heightened scrutiny since Musk's chaotic Twitter announcement on August 7 that he was considering taking Tesla private, before reversing the plan two weeks later.
Of 50 USA sates, recreational cannabis remains illegal in 41 - but it was legalised in California, where the podcast was filmed, in January.
Also on Friday, Bloomberg reported that Tesla's human-resources chief, Gaby Toledano, would not return from a leave of absence that began in August.
Musk told The Guardian in response to a question about whether Tesla drug-tests employees that "our policy allows trace amounts of THC [an ingredient of cannabis] during work times, provided they are below the safety limit (much like a minimum alcohol level)".
"It's legal right?" Musk asked, before Rogan said it was "totally legal" and the entrepreneur took a drag of the cigarette.More news: Police officer shoots neighbour dead after mistaking his flat for her own
More news: Liverpool still in preseason mode despite unbeaten start Jurgen Klopp
More news: British Airways suffers massive data breach, 3.80 lakh payments hit
If such a system is connected to your vehicle, it could calculate when you'll be home and start the air conditioning at the optimal time to save energy, Musk said. He had only been with the company for about a month.
"I think the future in where we are a space-faring civilization out there among the stars, that is very exciting", Musk said.
Musk in recent days also renewed a feud with a British cave diver, Vernon Unsworth, who was involved in the rescue of 12 boys trapped in an underwater cave in Thailand this summer, according to the BBC.
Morton, who is walking away from a $350,000 base salary and a $10 million new-hire stock grant that would vest over four years, said he believed "strongly" in Tesla and that he had no disagreements with the company's leadership or its financial reporting.
Just another installment in the extraordinary saga of Elon Musk, the billionaire leader of two major companies that are trying to change the world.
Tesla shares were trading down almost 7 percent at $261.45 at the time of publication Friday.
Tesla is facing increasing competition from other auto makers that are developing their own lines of electric vehicles.
Shortly after CNBC published its story, a reporter for Fox Business confirmed that the Air Force is investigating Musk's drug use.