And the results were mixed.
The US Open, the season's fourth and final slam, gets underway in NY on August 27. But this afternoon, opened and finished strong in his first career win over the Scot. From 2005 to 2006, Federer won 56 consecutive matches on hard courts.
The three-time grand slam victor failed to mount a prompt response and was soon on the back foot again on serve, an overcooked forehand giving Pouille another break-point opening. And Pouille hung on. "It's been good to me", Murray said.
"As long as I can serve, I have a good chance to win still". I physically felt okay. Little by little I'm gaining my confidence.
"It can be overwhelming, and I tend to be a perfectionist, and I like to do things at a standard that is maybe unrealistic, and that includes being a mum". Sock has lost eight consecutive matches since May.
"It was tight. He's a top 20 player".
On the men's side, Sam Querrey ground out a 6-4, 6-7 (5), 7-6 (5) win over fellow American and ninth-seeded John Isner. Pouille moved comfortably into a 2-0 lead and although Murray held serve in the next, he failed to convert a break point in the fourth game and fell 3-1 behind.More news: Islamic State claims Kabul's latest deadly attacks
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Wild-card Victoria Azarenka, a two-time Australian Open champion, also came from behind to beat Carla Suarez Navarro 6-7 (5), 6-2, 6-4.
Stan Wawrinka, on the mend after knee surgery, won 6-2 4-6 6-3 against Diego Schwartzman to set up a tie against Kei Nishikori, who beat Andrey Rublev 7-5 6-3.
In a marquee NextGen clash, Denis Shapovalov edged Frances Tiafoe 7-6 (6), 3-6, 7-5.
Nadal, the 17-time Grand Slam victor, collected his 80th career title on Sunday by beating Greek youngster Stefanos Tsitsipas 6-2 7-6 (7-4).
The 31-year-old Serb is searching for his first Cincinnati Masters title after five finals.
Number eight seed Kvitova applied the pressure from the start, breaking 23-time grand slam victor Williams twice in the first set. "I still have a lot of work to do, but I'm really positive with where I am right now". Anxious actually. Cincy has been a great tournament for me in the past.
Big-serving Czech Karolina Pliskova fired an ace on match point to dispatch Agnieszka Radwanska 6-3 6-3 in their first-round match.
But there will no repeat of those giant-killing feats in OH, where 11th seed Goffin dispatched the young Greek 7-5 6-3.