Fortunately, after a consultation in Barcelona yesterday it appears the injury will not require surgery, as previously anticipated.
Guardiola, whose side host Huddersfield tomorrow, admits the loss of De Bruyne is a huge blow.
Belgian journalist Kristof Terreur reported the news on Twitter and has stated that between 8 to 10 weeks is the normal recovery time for a lateral ligament sprain under specialist Dr Cugat.
The return of Silva is a timely boost for City and Fantasy Football enthusiasts, particularly for those who had been basing their early season charge on De Bruyne.
Tottenham have moved their first three fixtures to Wembley, where they played home games last season, but switching the City match to the national stadium is complicated because an NFL game scheduled for the same day.
Roberto Firmino, Sadio Mane and Mohamed Salah tore defences apart for fun last season and Liverpool ended up scoring 84 times in the Premier League, bettered only by Pep's City side. "We don't look at the other teams, we really only try to make the best of our situation, and that will hopefully work". "I think my biggest challenge as a manager is to change that", he says.More news: "Painful Year": Tesla Shares Fall After Elon Musk Interview Sparks Fears
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Many are tipping City as favourites to win the league once again this season, while they got off to a great start with a 2-0 win over Arsenal.
And with David Silva potentially ready to rejoin the fray for Sunday's visit of Huddersfield Town, Guardiola believes the 32-year-old Spaniard also still has a key role to play now that he has hung up his worldwide boots.
"We will see, but it is never easy to replace Kevin".
"More than 100 games, winning the World Cup, two European Championships as one of the most fascinating, incredible players in the history of Spain".
The Belgium global is set to miss City's first four Champions League games as well as the Spurs clash and another potentially key game against Liverpool on October 7.