Pogba was linked with a move to Barcelona earlier this week but the United board never had any intention of selling him.
Northern Ireland worldwide Jonny Evans - a former Manchester United player - is unlikely to feature in this one because of injury and it remains to be seen exactly how many World Cup stars either manager selects for tonight's showdown.
Both clubs finished below United last season in the English Premier League yet Mourinho claims they are projected as "serial winners" despite failing to land a trophy since 2012 and 2008 respectively. "Now it is time to prove it, to fight for the top spots, and I think this is the season to do it".
For the first time the EPL deadline has been moved forward to the day before the season kicks off when United hosts Leicester City today.
He went on to repeat his sentiments that United are in for a tough season, after they overcame opponents who spent more cash in the summer transfer market.
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Fresh off the back of a sensational World Cup-winning campaign this summer with France, Paul Pogba was thrown straight into the starting line-up for United, being given the captain's armband as well. I had my plans for many months and I find myself with the market closed in a situation I did not think I would be in.
Mourinho has made no secret of his disappointment that he was not able to significantly strengthen his team during the close-season.
"But you don't win anything with second and with Liverpool and Man City looking stronger than ever, I worry for them", he said.
Courtois' replacement at Stamford Bridge is Kepa Arrizabalaga, who became the most expensive goalkeeper in history when Chelsea paid his €80m release clause at Athletic Bilbao, but reports United are ready to make Leicester City's Harry Maguire the world's costliest defender now seem unlikely to come to fruition. "Maybe on the next game I leave it to Alexis".
I won't be full from a World Cup.
Asked if he had the tools to compete without new signings, Mourinho said: "I have my players, I like my players, I like to work with my players".