Cavani's brace in Uruguay's 2-1 win in Sochi took his tournament tally to three goals and condemned Portugal's talisman Cristiano Ronaldo to a World Cup exit, just hours after his great rival Lionel Messi took the same path.
Cristiano Ronaldo became the second big name player to crash out of the World Cup today after Portugal were beaten 2-1 by Uruguay.
Portugal equalized the game on a Pepe header in the 55th minute, but Uruguay regained the lead seven minutes later on a break from a goal kick.
Cavani then had to be helped off by Ronaldo before watching the rest of the game from the dugout with ice on a calf injury.
Two-time world champion Uruguay hadn't reached the last eight at the World Cup since a fourth-place finish in 2010.
Luis Suarez of Uruguay and Diego Godin of Uruguay celebrate at full time. Ronaldo ran in front of Pepe and drew the attention of both Gimenez and Godin. A move he started with an exceptional 40-yard cross-field pass to strike partner Luis Suarez, he finished with an equally impressive dive to meet Suarez's return at the far post.More news: LeBron James contacts Kevin Durant about leaving Golden State Warriors
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Uruguay is the only team that didn't concede a goal in the first round - in a group containing Russia, Saudi Arabia and Egypt. In between all of the gorgeous goals, ugly own goals, and remarkable upsets, Ronaldo helping Cavani get off the field will likely go down as one of the tournament's most memorable moments.
Fernando Santos is Portugal's current coach. With the help of a red card and an own goal, Uruguay wrapped up group play with a 3-0 rout of host Russian Federation, taking the group with nine points. "Even if he scores three goals in match, you still need to have a team to support him". KEYS TO THE GAME Stopping Ronaldo.
Despite being one of just five teams to have won the World Cup a few times and boasting two of the finest strikers in European soccer in its attack, Uruguay flew under most people's radar heading into the World Cup.
It was a five-pass buildup from deep in their own end that culminated in Uruguay's first goal, and the final two passes were flawless.
And as he limped off the pitch, he was given a helping hand courtesy of Portugal's captain. The Uruguayans had gone 598 minutes since November 2017 without allowing a goal.