Ramos has been football's supervillain number 1 after his role in the injury to Egypt and Liverpool star Mohamed Salah in the Champions League final in May.
Spain were level five minutes later when some crisp passing sent Iniesta free inside Morocco's box. But the reality is that at some point a team has to make the kind of difference-making plays - at both ends of the field - that propel a side into the second round, and Morocco didn't make almost enough of them.
Substitute Iago Aspas struck in stoppage-time to earn Spain a dramatic 2-2 draw with Morocco on Monday which gave them top spot in World Cup Group B and a place in the last 16. Clearly stung, *La Roja* took just five minutes to reply, with Iniesta slipping the ideal pass to Isco, who fired home from close range.
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"It will be tough game against the hosts, it will be a packed stadium", said Spain coach Fernando Hierro who took charge of the team two days before the tournament following Lopetegui's sacking. The Moroccan players could go home with their heads held high.
The Spaniards will now face World Cup hosts Russian Federation in the second round after Portugal were held to a 1-1 draw by Iran in the night's other game.
"We would have loved to get a win over Spain, this is why we came here tonight".
Defending ruggedly and breaking out in fast counter attacks, Morocco were a constant threat and came close to taking the lead earlier when Noureddine Amrabat rattled the goal frame with a powerful shot in the 55th minute that David De Gea could only watch as it bounced down to safety.
In team news, Thiago Alcantara is expected to replace Andreas Iniesta in central midfield and the Bayern Munich player could have a telling impact against Morocco.
The result, combined with Portugal's 1-1 draw against Iran, sees Spain through to the round of 16 as group winners because of total goals scored and will now face Russian Federation in the knockout round. Portugal's 1-1 draw with Iran left Ronaldo's team second and facing a knockout match against Uruguay on Saturday in the next round.