Sane's performances for City earned him the PFA young player of the year award as he scored 10 league goals and added 15 assists, second only to team-mate Kevin De Bruyne in that category.
Chelsea trio Cesc Fabregas, Pedro and Alvaro Morata all miss out while the frightening depth of France's talent pool means the likes of Anthony Martial, Alexandre Lacazette and Karim Benzema will also be left at home.
He will, however, play no part for his country in Russian Federation this summer after being cut from coach Joachim Low's 27-man preliminary party.More news: Barcelona president: 'Samuel Umtiti release clause set at £438m'
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The 'keeper said his careful reintroduction had been a deliberate ploy - he didn't play a single match for Bayern before joining up with the national squad.
"It was a very close decision. If it was a 100m race, it would have been a photo finish".
"I'm obviously disappointed I won't participate in the World Cup", he wrote. Are Southgate's tactics good enough to win England the World Cup, and should Vardy start with Kane?
Sane, capped 12 times by Germany so far, added: "Nothing but the best of success to the DFB team in Russian Federation".