Dimmit County Sheriff Marion Boyd says the SUV went out of control at more than 100 miles per hour and overturned on Texas Highway 85, ejecting those inside. Dimmit County deputies took over the chase near Big Wells, Texas.
Boyd credited "good police work" for the reason why deputies started pursuing the vehicle, News 4 San Antonio reported, adding that Boyd said human smuggling was a "real problem" in the area.
Dimmit County officials confirmed Sunday afternoon that five people have died in a crash involving undocumented immigrants.
The driver, a suspected smuggler and also believed to be a US citizen, survived the crash, according to NBC News.
Twelve immigrants were ejected when the vehicle crash.
The crash took place in the city of Big Wells outside San Antonio after Border Patrol agents tried to stop the driver of an SUV, ABC television affiliate KSAT reported.More news: Federer wins 98th ATP title ahead of world number one return
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Four of the migrants reportedly died at the scene, with a fifth later dying at the hospital.
"Our deepest sympathies go out to the families of those who died in the crash", The Border Patrol said in the statement.
Boyd said the driver of the Suburban was also injured and was flown to a San Antonio hospital. "It's a problem. This is, I think, a flawless example of why our borders need to be secure".
"If it can be built, then I think it should be built, but along with that, I think there needs to be cameras", Boyd said. "We dealt with him last week", Boyd said.
Yolanda Choates, a US Customs and Border Protection spokeswoman, directed questions to the Dimmit County Sheriff's Office.