They'll play the winners of group H - one of Japan, Senegal and Colombia - in Moscow on Tuesday, kick-off 7pm.
When the match kicks off, both teams will be able to plot their potential route through to the final, as this is in the last pair of group stage matches.
As it stands - thanks to a few quirky results - one side of the draw appears considerably more hard.
With 35 Premier League players from the 2017/18 campaign playing for either England or Belgium during the World Cup there will be plenty of familiar faces on show.
Germany's Group F exit has blown one side of the draw wide open, but Southgate said his side feared no one after making an encouraging start in Russian Federation.
As it stands it may actually prove more beneficial to finish second in the group as those who top it are on course to face Brazil in a possible quarter-final, compared to the prospect of either Switzerland or Sweden in the quarter-final for whoever finishes second.
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'We want to win football matches, we are not happy to come away beaten but what that means for the next round we don't really know.
The match was far less dramatic than the day's earlier games, but the outcome still had consequences that could affect both teams as they look to continue their World Cup runs into the knockout round.
Stones took his seat on the England bench for the second half and could been seen sporting some heavy-looking strapping and ice around his left calf area - something that was apparently not immediately picked up by television commentators. "The reality is we put ourselves in this situation we wanted to qualify, and we have done that".
In the very last of the group stage games, the scenario was uncanny.
How both sides approach the match will be a good indicator of their respective philosophies and team culture.
Southgate has made it plain that he wants that to be England, but nonetheless he won't be fielding his first XI, with Eric Dier, Gary Cahill, Phil Jones and Trent Alexander-Arnold all expected to make their World Cup bows. Harry Kane continues to lead the line but Marcus Rashford is preferred to Raheem Sterling and Jamie Vardy as the captain's strike partner.
The players' performance will also be a factor in who wins the golden ball (the tournament's best player).