Belgium coach Roberto Martinez will field the same starting XI which beat Panama 3-0 on Monday, hoping for three points that would all but qualify his side for the next round before they face England on Thursday.
The score line afforded coach Martinez the luxury of resting his top guns, understandably with an eye on the tie against England in battle for top spot in Group G.
The only competitive World Cup fixture between the two sides ended in a 1-1 draw, with former Belgian manager Marc Wilmots on the scoresheet.
Belgium and Tunisia team captains toss the coin before their match at World Cup 2018.
Hazard left the game in the 68th minute, with Germany's Andre Schurrle and Toni Kroos, who did so in the 7-1 victory over Brazil in the semifinals in 2014, the last two players to score two goals each in a World Cup game.
In what has been a hugely productive 2017-18 campaign, Lukaku has followed up his 27 goals in all competitions for United with seven goals for Belgium in June alone.
Mitchy Batshuayi, in for Hazard put the icing on the cake albeit after three failed attempts, to round off a spectacular Belgian performance, helped by a surprisingly a pedestrian Tunisia.
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With less than five minutes on the clock, Hazard was brought down by Syam Ben Youssef.
The Red Devils' best run at a World Cup is third place in 1986 but they are regarded as dark horses for the title in Russian Federation.
Belgium were much the better team from the off, but they were seriously aided by poor defending.
After receiving two goals in the net from Belgium Tunisia scored one against Belgium.
Belgium take on Tunisia on Saturday with their eyes set on the knockout round of the World Cup but fearful that star forward Eden Hazard is set for another bruising encounter.
They are yet to lose to African opposition at a World Cup, while Tunisia have never beaten a European side at a finals.
Bats broke his spell in the 90th minute and scored Belgium's ninth goal in two games.
Tunisia also used pace and direct running to expose Belgium's defense, though tested goalkeeper Thibaut Courtois too rarely.