Borja Mayoral pulled one back, before Ramos converted his second penalty of the match in stoppage time, but they left their fightback too late and Zidane was forced to defend his line-up.
Real Madrid know their season hinges on the Champions League final on 26th May, meaning their trip south is less than important than it would have been in past seasons.
Up stepped Ramos to convert the spot kick, but the defender struck the underside of the crossbar with the shot and it bounced clear.
In the last five matches, Sevilla FC has won one match, lost two matches, and drawn two matches whereas Real Madrid has won two matches and drawn three games.
Incredibly the action did not stop there as Madrid were awarded a second penaltyof the match in the fourth minute of added time after an off the ball incident between Mercado and Theo saw the Madrid man hit the deck.
Real Madrid striker Borja Mayoral now second most effective goalscorer at club
"We were good in first three quarters of the pitch, but we did nothing in the last 30 metres, nothing on the second line, nothing to worry the opponent".
Despite the defeat, Real Madrid remain third in the table with 72 points from 36 games while Sevilla moved to seventh position with 54 points from the same number of matches. "Above all the first half, the second half we had better movement". Zidane denied he had erred by leaving big names including Luka Modric, Toni Kroos, Keylor Navas and Marcelo back at home in the capital.
"When you look at the team we have put out, I think it's a team that could win".
No matter the professionalism and quality of Real's players there is little doubt they will have the Champions League final in the back of their minds in their closing La Liga games.
"Not at all, every player I have is competent". He said, "Barcelona did the pasillo at the Bernabeu, 10 years ago when we won the league and I experienced that".More news: Video Shows Florida Deputy Saving Unresponsive Baby
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