At one point midway through the afternoon, four players - Uihlein, Bryson DeChambeau, Charl Schwartzel and Aaron Wise - all held a share of the lead, but it was Jason Day - already a victor this season on the PGA Tour and playing the Wells Fargo Championship for the first time since 2012 - who emerged from the crowd thanks to back-to-back birdies at Nos.
The former world No.1 made back-to-back birdies on the 16th and 17th - at which he nearly made a hole in one when his 230-yard tee shot hit the flag - on his way to a two-under par 69 at Quail Hollow and 12 under total.
Day, who captured his lone major crown at the 2015 PGA Championship, stood on 10-under 203 after 54 holes at Quail Hollow in Charlotte, North Carolina.
Peter Malnati's 36-hole lead didn't last long.
However, Woods made a strong return this year, claiming that his back woes were behind him and proving it with a stretch of three straight top-12 finishes, including second at the Valspar Championship in March.
He and the rest of the field will hope for a better performance next week in the high-profile Players Championship at TPC Sawgrass.
Tiger Woods completed a disappointing week with a 74 in Round 4, featuring three bogeys and 15 pars.
The ensuing three-feet birdie restored his two-shot lead and he parred the last to finish at 12-under 272. "I knew that if I could just get myself in position...don't do anything too silly out there and find a way to get back into the swing of things, that I could come out of this on the better half".
"I had no idea where the ball was going today, especially off the tee", Day said.More news: European visitor may have exposed WNYers to measles
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Jason Day leads at Quail Hollow, chasing his second PGA Tour win of the year.
Langer had to rally from as many as four shots behind in the final round at the The Woodlands Country Club.
After failing to get up-and-down on the par-3 13th, he pulled his tee shot into the lake left of the short 14th. Langer was behind a TV structure, however, and chose to take relief to the right away from the trees. It was the shot that won the tournament for him. He went just right of the green, hit a delicate chip to just under 4 feet and made the putt. Paul Goydos (68) led for much of the back nine until a bogey on the 18th hole. He tied for second with Jeff Maggert and Bart Bryant, who each had a 69. Watney hasn't won in almost six years. It was Langer's fourth win at the Insperity Invitational.
This was his 38th worldwide start since that win, and there were all manner of issues that cropped up.
Phil Mickelson opened with two bogeys, failing to capitalize on the momentum from his third-round 64.
The victory moves to Langer to the top of the Charles Schwab Cup standings. McIlroy three-putted the 18th and still shot 5 under.
Frustration was the name of the game for both Rory McIlroy and Tiger Woods, as their respective attempts to use the final round of the Wells Fargo championship at Quail Hollow as a morale-boosting dress rehearsal ahead of The Players proved to be an elusive ambition for each of them.
Park was the LPGA Tour rookie of the year and shared the LPGA player of the year award with So Yeon Ryu last year. Park finished with a two-round total of 11-under 131 for her third LPGA Tour victory.