The two pilots ejected and parachuted to safety in Israel.
"We can hear the sounds of the explosions", said one Damascus resident, who spoke on the condition of anonymity.
According to the statement, 12 targets were attacked inside Syria, including three Syrians air defense batteries and four Iranian targets that were part of Iran's buildup in Syria.
A military expert talked to Sky News Arabia TV, revealing that he obtained "news that the Israeli F-16 fell inside the Jordanian territory". Jonathan Conricus said. The IDF later released footage of what it said was the drone's control vehicle in Syria being destroyed. The targeting of Iranian sites in response, however, marks an escalation in the Israeli retaliation.
Israeli missiles also this week targeted a Syrian military research center near Damascus.
Tensions on Israel's northern border have been rising in recent months as Israel fears that Iran is entrenching itself deeper into Syria with its presence on Israel's borders growing in strength.More news: New Kingdom Hearts III Trailer Reveals Monsters, Inc
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Israel has long complained about the involvement of archenemy Iran, and Iranian proxy Hezbollah, in the Syria war.
In a meeting with Russian President Vladimir Putin last month, Netanyahu reportedly sought to assure Israel's freedom of action as it attempts to thwart the transfer of weapons to Lebanon-based Hezbollah through Syrian territory.
"This is a serious Iranian attack on Israeli territory".
Mishal said that his friends and neighbors in the town started sharing text messages and social media posts, with rumors flying around about what had happened, until 8 a.m. when the news stations gave details of the Iranian drone being shot down.
The IDF said it would "act determinately against such severe violations of Israeli sovereignty by Iran and Syria".
According to a separate military statement, "multiple anti-aircraft missiles were fired at IAF (Israel Air Force) aircraft".
June 24-26, 2017: Israel kills 13 Syrian soldiers in repeated attacks on Syrian military targets in Quneitra. He said: This will be seen as Iranian aggression.
Air raid sirens had gone off in Israel in the early hours of the morning following the UAV interception and raids. The heavy fighting in recent days in the northern Syrian province of Idlib has also threatened to bring Iran into conflict with Turkey, which is now waging a brutal military campaign against Kurdish fighters in Syria.