Investigators say he was deported to Guatemala in 2007 and again in 2009.
An ICE detainer is now placed on Orrego-Savala while he remains in Marion County Jail.
Jackson had pulled over after he felt sick and was being helped by another driver, 54-year-old Jeffrey Monroe, who was also struck and killed.
Police said after the truck hit them, Orrego-Savala then tried to flee the scene on foot before being arrested.
On Monday, Indiana State Police (h/t Wells) announced that Gonsales is in the country illegally and was driving without a license. Police say they're working with prosecutors on potential criminal charges. He had gone out with Jackson the night he was killed.More news: Wenger reveals why Arsenal let key attacker leave in January
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Orrego-Savala is a Guatemalan citizen who's in the US illegally. One of the bodies landed in the middle of I-70. After an unauthorized immigrant was acquitted after killing a 32 year-old woman walking with her family on a San Francisco pier, Trump lashed out at the city's "sanctuary city" status. This is a great loss for the entire IN community.
Jose Ines Garcia Zarate, who was acquitted of murder on November 30 in Kate Steinle's death, had been deported five times and was wanted for a sixth deportation when she was fatally shot.
In court this morning, Orrega-Savala said through a court interpreter that he wasn't driving the auto, WRTV reported.
Monroe and Jackson were pronounced dead at the scene by the Marion County Coroner's Office. ICE said it has placed an immigration detainer on Orrego-Savala at the Marion County Jail.
"Edwin was loved by all in the Colts organization", the team said. We admired his outgoing personality, competitive spirit and hard-working mentality. This is a great loss for the entire IN community.
Linebacker Jackson, 26, was signed by the Colts in January 2016 and played parts of one season in the league.