Jackson was 26 years old.
President Trump on Tuesday called Jackson's death another "preventable" and "disgraceful" tragedy. Joe Donnelly, D-Ind., said in a tweet Tuesday. The president also prodded Democrats to work with him on illegal immigration and border security. "We also thank Mr. Irsay and the entire Colts organization for allowing Edwin to fulfill his dream of playing the game that he worked so hard for and loved immensely".
Orrego-Savala said he hired an attorney.
The case could have implications for the ongoing immigration debate in Congress over so-called Dreamers, young unauthorized immigrants whose fate is up for negotiation.
"State police investigators are working with US Federal Immigration Officials and they have placed a hold on Orrego-Savala". Indianapolis television station WRTV reported that Orrego-Savala told the judge through an interpreter: "I wasn't driving the auto".
Orrego-Savala was taken to the Marion County Jail, accused of driving without a license and on suspicion of intoxicated driving. The two more serious counts each carry a maximum sentence of 20 years in prison.
Widow of Uber driver killed by a suspected drunk driver over the weekend said she isn't surprised that her husband was outside his vehicle helping Colts player Edwin Jackson when he died because that's just the type of person he was.
A Marion County judge entered a not guilty plea for 37-year-old Manuel Orrego-Savala during a court hearing Wednesday.More news: Scientists Create First Lab-Grown Human Eggs
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When Orrego-Savala appeared before the judge he was assisted by an interpreter. Police say he slammed his Ford F-150 pickup into Colts linebacker Edwin Jackson and Uber driver Jeffrey Monroe as they were standing on the emergency shoulder of Interstate 70 in Indianapolis early Sunday morning.
"Drunk driving has nothing to do with immigration status". He had entered the USA illegally in July 2004 and he was convicted of driving under the influence in Redwood City, California, in 2005, ICE said.
Immigration officers first arrested Orrego-Savala in San Francisco in 2006, an ICE spokeswoman confirmed Monday evening. A federal immigration charge was filed against him Tuesday.
Manuel Orrego-Savala, a citizen of Guatemala, leaves a court hearing in Indianapolis on February 6.
Officials say he was nearly 3-times above the legal limit.
Authorities say Orrego-Savala, a citizen of Guatemala, was deported in 2007 and 2009. They recalled him as being caring and amusing.
Police say the 26-year-old Jackson and 54-year-old Uber driver Jeffrey Monroe were standing outside Monroe's vehicle along I-70 after Jackson became ill while Monroe was transporting him.
Both men were outside the auto when a black Ford F-150 drove into the shoulder and struck the vehicle, killing them both.