Sitting presidents have rarely attended the event, held at a ski resort in the Swiss mountains, fearing its reputation for elitism may not play well politically at home.
"The president welcomes opportunities to advance his America First agenda with world leaders", Sanders said.
But White House press secretary Sarah Huckabee Sanders said Mr Trump would be promoting his policies for strengthening American businesses, industries and workers.
The White House's announcement on Tuesday that Trump would attend this year came as a surprise.More news: Oprah Should Not Be President
More news: HTC Launches Viveport VR
More news: GoPro Drone Business Crashes
Chinese President Xi Jinping participated in the conference a year ago.
That year's gathering, which occurred around Mr Trump's inauguration, was viewed as a sign of China's ascendance at a time of growing American isolationism.
President Donald Trump will attend the annual meeting of world financial elite in Davos, Switzerland, a celebration of globalization and free trade that runs counter to the "America First" populism he champions.
In a separate statement, Klaus Schwab, the founder of the forum, said Trump would offer a "direct perspective" on the U.S.'s priorities and that the president would be accompanied by key Cabinet ministers and USA lawmakers. Neither George W Bush nor Barack Obama visited the conference.
Bill Clinton attended Davos in 2000, the only president to do so, and he has been a regular attendee since.