At the end of the study, the men who took ibuprofen had developed compensated hypogonadism, a condition usually associated with smokers, elderly men and those with reproductive issues or physical disorders.
Young men taking ibuprofen saw a coordination between luteinizing hormones (LH) - those that produce testosterone - and the level of ibuprofen in their bloodstream. "Based on these data, I personally would be very reluctant to take ibuprofen for longer than the 10 days normally indicated on the packet". The men were then divided into two groups, 14 in an ibuprofen group and 17 in a placebo group.
"It is also associated with depression and increased risk for cardiovascular events, including heart failure and stroke". This rose to a 23% decrease after 44 days.
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HollywoodLifers, did you know the negative effects of ibuprofen?
The researchers also pointed out the risk of those with compensated hypogonadism progressing to overt primary hypogonadism, which is characterized by "low circulating testosterone and prevalent symptoms including reduced libido, reduced muscle mass and strength, and depressed mood and fatigue". Inhibition of testosterone levels was found to be significant and dose-dependent after 24 and 48 hours of ibuprofen exposure (in doses which corresponded to the oral doses used in the trial). So not only is the shrinking of your balls concerning on a personal level, it could also suggest you're going to die earlier.
According to the results of their study, taking aspirin, acetaminophen or ibuprofen during pregnancy can lead to complications with regards to the development of babies.
A study of nearly 1,000 men tracked for seven years found that twice as many with hypogonadism died as did those with normal testosterone levels. But researchers are concerned about long-term use among athletes.
The new study isn't the first to suggest that ibuprofen has downsides.