Murray has not played a competitive match since losing to Sam Querrey in the Wimbledon quarter-finals in July after a hip injury curtailed his 2017 season.
"I came here with every intention of making a strong start to the year, but sadly my team and I don't feel that I'm where I need to be just yet to compete at the highest level", the two-time Brisbane International champion said in a statement. "I'm aware of the situation at the end of past year (2017) especially because for tennis and the sport it's not good", Murray said of the injury situation.
"I've obviously been going through a really hard period with my hip for a long time and have sought council from a number of hip specialists", the three-time grand slam singles champion and two-time Olympic gold medallist wrote alongside a picture of himself as a schoolboy.
BC-TEN-Brisbane International-Murray Out, 1st Ld-Writethru, 204 Injured Murray withdraws from Brisbane InternationalAP Photo XKJ129Eds: Updates with quote, detail. I didn't realise until these last few months just how much I love this game. "I want to wish Garbine a fast recovery and I hope she gets better for the Slam".More news: Mariah Carey's New Year's Eve performance complaint takes internet by storm
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Fifth-seeded Johanna Konta reached the quarterfinals with a 4-6, 6-1, 6-4 win over Ajla Tomljanovic and Alize Cornet advanced with a 6-1, 7-5 win over Mirjana Lucic-Baroni.
Murray had planned to use the Brisbane event as his main warmup for the Australian Open starting January 15 in Melbourne. Having played practice sets here in Brisbane with some top players unfortunately this hasn't worked yet to get me to the level I would like so I have to reassess my options.
"Obviously continuing rehab is one option and giving my hip more time to recover", Murray wrote in an Instagram post. And although he has done everything he can to avoid surgery on what has now become a chronic hip issue, he seems to be at the point where he's considering it - even if, as he points out, there is no guarantee of a successful outcome.