Williams who gave birth to her first child earlier this year will play current French Open victor Jelena Ostapenko on day three (December 30) at 5pm as she prepares for the year's first Grand Slam next month.
Playing her first match since winning the Australian Open in January, the 36-year-old former world number one - who became a mum for the first time in September - looked far from full fitness but that was understandable.
The 30-year-old is scheduled to participate in the Brisbane International which starts December 31 as he gears up for the Australian Open, but a season blighted by injury has changed the double Wimbledon champion's outlook.
It is a surprise to see the American back in action so quickly, but she definitely has her eyes on a 24th Grand Slam trophy in Melbourne, but made a decision to compete in Abu Dhabi for her comeback, "I am delighted to be returning to the court in Abu Dhabi for the first time since the birth of my daughter in September".
Serena Williams was "excited to be back" after completing her first match since giving birth fourth months ago.
"Serena is the greatest women's tennis player of all time, and perhaps the greatest competitor -- man or woman -- that I have seen".More news: Russia: Several injured after blast in Saint Petersburg supermarket, say police
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"It's my first time playing in Abu Dhabi so thank you guys for the support".
"I am really honoured to play Serena in her first match after coming back and I think it is such a great opportunity for me. I want to become a more consistent player in 2018", she added.
"It's pretty wonderful to play Serena and it's a great place to be here. It was a really great clay-court season, there I was putting the base for all the good ranking, for all the London thing and everything so of course I try to play as successful as I did".
"It can be one of two matches and everything comes back again but those one or two matches just didn't happen when I needed them at the end of last season and yeah I hope and I think that it's going to happen next year".
"To do well here would be an awesome feeling but I'm not going to weigh my whole year and rest of career on the next three, four weeks", she said.
"I don't know if I am totally ready to come back on the Tour yet".