Banks in Hawick, Selkirk, Jedburgh, Duns, Eyemouth and Melrose are due to shut in the next 6 months.
The Skelmersdale site was included in the 62 Royal Bank of Scotland and 197 NatWest branches which are to close.
Today's reductions follow 360 redundancies earlier this year and bring the total number of branch closures announced since March to more than 400. In England and Wales the number of NatWest branches will fall to 655.
'We provide our customers with more ways to bank than ever before, ' she said. Since 2014 the number of customers using our branches across the United Kingdom has fallen by 40% and mobile transactions have increased by 73% over the same period.
It said more than five million customers now used its mobile banking app and one in five only bank with RBS digitally.
NatWest in Kingswinford
"This announcement will forever change the face of banking in this country resulting in over a thousand staff losing their jobs and hundreds of high streets without any banking facilities".
"We have extended the time between announcing our decision and the branch closure to six months; this has been done so that we can ensure our customers have enough time to consider the right banking options for them and to give us time to support them one-to-one during the transition".
But the trend has prompted fears for communities being left without a bank in their town and those unfamiliar with the developments of the digital age being cut adrift.
RBS intends to help more people bank online by introducing TechXperts to teach people to use online services.
Last week, the Government disclosed 2018/19 plans to sell around two-thirds of its RBS stake, which would equate to about £15bn over five years.More news: Europe's Muslim population to grow strongly
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