According to a spokesperson from the Loudoun County Sheriff's Office in Virginia, the actress had her mug shot taken and was released on a $5,000 bond.
Following her release, the actress spoke to the New Yorker's Ronan Farrow.
McGowan has been a leading voice among the sexual harassment accusations against Hollywood mogul Harvey Weinstein.
According to a previous New Yorker report, Weinstein operatives using false identities met with McGowan in fall 2016 to try to get information from her after she had tweeted about being raped by a studio head, and again in 2017.
Weinstein is alleged to have hired a team of private investigators to smear victims and try to keep a lid on allegations in the run-up to a wave of revelations being made public.
Rose McGowan will plead "not guilty" in her felony drug possession case.
Weinstein has unequivocally denied all allegations of non-consensual sex.
She said: "I had it in the side pocket of my backpack, and I left it on my seat as I went to the bathroom".More news: Miranda Kerr, Evan Spiegel expecting first child
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A month ago, McGowan uncovered on Twitter that she was confronting a warrant for her capture.
McGowan noticed the wallet missing when she was trying to hail a ride service from the airport ahead of the January 21 Women's March on Washington, she told the magazine.
A warrant for the Charmed star's arrest was issued earlier this year when two bags of cocaine were discovered in her purse after it was found on a United Airlines plane.
Then, in 2016, the actress says she encountered Weinstein at the same hotel, this time to "celebrate her upcoming role in Marco Polo" (she did not end up getting the job).
With that said, Rose said she had no plans to do cocaine during the Women's March.
"I have been silenced for 20 years", McGowan said at the convention.
Apparently, the warrant was from Loudoun County, Virginia, officials.