"In coordination with the Federal Government of Somalia, US forces conducted an air strike in Somalia against an Al Shabaab camp on Tuesday, November 21 at approximately 10:30 am local Somalia time, killing more than 100 militants", the US Africa Command said in a statement.
The rival group to Al-Shabab has established a presence in the semi-autonomous state of Puntland in the north of Somalia.
The military's Africa Command said the strike was carried out on a camp 125 miles (201 km) northwest of the capital, Mogadishu and that the United States would continue to target militants.
The strikes have predominantly targeted Al-Shabab, the group affiliated with Al-Qaeda that has been waging an insurgency against the Somali government since 2006.
The US military has in recent months upped the tempo of its operations in Somalia, conducting a growing number of drone strikes against al-Shabaab and other militants.More news: Nigeria police say at least 20 killed in mosque bombing
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The personnel are part of the effort to support African forces fighting al-Shabaab as well as the ISIS forces there. "It is just.propaganda", he told Reuters in Somalia.
In the statement, the armed forces reiterated their intention to "use all authorized and appropriate measures to protect Americans and to disable terrorist threats".
The group is responsible for one of the largest suicide truck bombings in history, which killed more than 300 civilians in October.
There have been 29 strikes acknowledged by the Pentagon so far this year.
"Al-Shabaab has publicly committed to planning and conducting attacks against the US and our partners in the region", the USA military statement said.