For the past few years the Gunners have forced to accept Sanchez being overworked throughout the summer on global duty, reporting back for club duty without a long break.
Arsene Wenger has cast doubt over whether Alexis Sanchez will be involved for their Premier League clash against Watford this weekend, after the Chile worldwide received "special treatment" on global duty. If he survives the test he will play.
"The player I expected least to lose in the break was Mustafi".
Bernardo Silva, one of City's marquee signings in the summer, has made just three starts this season because of the level of competition he faces at the Etihad Stadium.
Calum Chambers could fill in for one of his defensive teammates, the centre-half having signed a new deal at the club.
But while Arsenal have yet to make a concrete offer amid reported interest from clubs like Manchester United, Ozil hasn't ruled out extending his contract with the Gunners, the source said.More news: Flu shot now available across Nova Scotia
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Ozil is back in training after recovering from a knee injury and could play against Watford on Saturday but Sanchez will have to be assessed following Chile's agonising defeat to Brazil.
Wenger might have given them an opening after admitting there is possibility that the two could be could.
Asked if he was anxious about Sanchez's mental state, Wenger said: "I will have to speak to him".
Another possible departure from Arsenal in January is Jack Wilshere, after reports indicated he was considering leaving the club in order to force his way into England's World Cup squad.
Wenger also revealed that former Arsenal midfielder Marc Overmars will not be returning to the club as Director of Football. "At the moment, we are not close enough to announce anything".