Mane picked up the problem on global duty with Senegal and was withdrawn late on in Saturday's 2-0 World Cup qualifying triumph over Cape Verde.
Liverpool striker Sadio Mane is facing up to six weeks out of action after picking up a hamstring injury on global duty with Senegal, the Premier League club said on Tuesday.
The timing is also all wrong for the manager, with high-flying Manchester United visiting on Saturday morning and Klopp needing a positive result to kick-start Liverpool's season.
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Mane has endured a tough start to the season, having already been suspended for three domestic games after being sent off for a high foot versus Manchester City.
Jurgen Klopp's side have some genuinely crucial matches coming up in the next few weeks, both in the Champions League and Premier League.
Mane has netted three goals for the Reds so far this season and is behind just Mohamed Salah and Roberto Firmino in the scoring charts.
Since his debut in August 2016 Liverpool average 2.2 Premier League goals with Mane in the team, compared to 1.6 goals in his absence.