The storm, caused by a "weather bomb" of low pressure in the Atlantic, has already struck the western coast of Ireland with heavy rain and is due to hit western parts of the United Kingdom at 4am on Saturday, as some families begin their half-term holidays.
Storm Brian is expected to hit Co. The Met Office, in collaboration with Ireland's Met Éireann, began naming storms in 2015-16 to raise awareness and prevent confusion between different storms.
People have been advised to stay away from exposed coastal areas and urged not to take so-called "storm selfies" as high tides and a storm surge create risky conditions along some coasts.
A weather warning is out for this weekend and the Environment Agency has issued a string of flood alerts.
Sky News weather presenter Jo Wheeler said the disruption was likely to continue on Saturday as the storm "will bring 80mph gusts to south-western coasts". In exposed places, the wind could cause damage to buildings or trees, and in coastal areas there will be high seas, spray and possibly coastal flooding.
Also known as explosive cyclogenesis, the weather bomb creates a jet stream of strong winds high up in the atmosphere which interact with the low pressure system.
Today, Network Rail also warned residents to tie down garden furniture during Storm Brian - to stop trampolines from blowing on tracks.More news: Judge temporarily stops gov't from facilitating abortion for illegal immigrant teen
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It follows Storm Aileen, the first UK-named storm of the season, which left thousands of homes without power last month.
Ophelia, meanwhile, was a North Atlantic hurricane named in Miami and made a rare turn towards Britain and Ireland - explaining the alphabetical difference between it and Brian.
"Those wind speeds can cause impacts to transport and power supplies, and the potential for unsafe waves also brings risks to coastal routes and communities, as well as the potential for flooding of homes".
And ahead of its arrival, the Met Office has issued a weather warning.
"Thursday's storm brings a risk of 60-70mph gusts around the south-west and Channel coasts", said Jo Wheeler.
And there's also a Twitter account that's already dedicated to it.