Cain's decorated 13-year career came to an end and the home crowd at AT&T Park saluted the right-hander, a cornerstone of the team's championship era who pitched the only flawless game in franchise history. San Francisco almost pulled off a series win over the playoff-bound Arizona Diamondbacks this week but surrendered three runs in the ninth inning on Wednesday and allowed the winning run to score on a bases-loaded walk in a 4-3 setback.
After having announced his retirement earlier in the week, Cain shut out the Padres on two hits over five innings in his first outing since August 29.
Giants closer Sam Dyson (3-4) retired the first batter he faced, but usually reliable shortstop Brandon Crawford threw wildly to first base on Christian Villanueva's slow roller, allowing him to reach second.
Stratton recorded a quality start against the Arizona Diamondbacks on Sep. Matt Cain went five scoreless innings in his final career start, giving up just two hits while striking out four. He gave a long leash to starter Johnny Cueto, who scattered 12 hits and four earned runs over five up-and-down innings of work. San Francisco is 4-1 in their last 5 home games and 1-5 in Cueto's last 6 home starts while the under is 8-2 in their last 10 division matchups.More news: United Nations 'carefully optimistic' on Fatah-Hamas reconciliation
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Padres right-hander Craig Stammen (2-4) walked the first batter he faced, Ryder Jones, to lead off the Giants' seventh.
Unlike the Tigers, who have already fired manager Brad Ausmus and had Andrew Romine play all nine positions in their Saturday win, the Giants were determined to fight until the end.
Fans, media, teammates and more took to Twitter to appreciate Cain's storied Giants career.
SAN FRANCISCO-At long last, the Giants were back in the heat of the race.