Beyond BRCA, Study Reveals 72 Mutations That May Lead To Breast Cancer

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Fortunately, today's breast cancer screening technology has advanced tremendously since 1985, and since I was diagnosed with cancer more than 11 years ago.

It means that for one in five women their genes mean they have nearly a third higher chance of contracting the disease.

But according to research by the American Cancer Society, U.S. breast cancer death rates have dropped almost 40% from 1989 to 2015.

The Somerset-based organization works to provide support and advocacy for African-American women affected by breast cancer. Healthy, non-cancerous breast tissue had more of a certain type of bacteria, but the cancerous tissues had other types of bacteria that were elevated.

"If you can differentiate women into groups of sufficiently different risks, you might be able to save more lives", Roger Mine, lead researcher of the "Nature Genetics" study and co-author of the "Nature" study, said.

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Around 70 per cent of all breast cancers are fuelled by the sex hormone oestrogen and respond to hormone therapies such as tamoxifen.

Baroness Delyth Morgan, chief executive of the charity Breast Cancer Now, said: 'This is another exciting step forward in our understanding of the genetic causes of breast cancer. In the last couple of decades, breast cancer-related mortality has shown a declining trend because of early detection and improved treatment.

'Crucially, the discovery of 10 new genetic variants that predispose women to ER-negative (oestrogen receptor negative) breast cancer could be particularly important'.

Researchers hope to develop a blood test to identify genes linked to breast cancer. "Of course, some of that is genetic, but three out of four women who develop breast cancer have no family history of the disease", explained Crestwood Women's Center Breast Care Manager, Julie McCain. However, we have developed a mathematical algorithm that incorporates the effect of each of the variations worn by a woman and which calculates from this the probability of her developing breast cancer, " says Simard, who sees in this new tool a way to identify women without a family history of breast cancer or ovarian cancer, but who are at high risk of suffering from such a cancer.

"These findings add significantly to our understanding of the inherited basis of breast cancer as well as identifying new genetic variants, we have also confirmed many that we had previously suspected", study investigator Doug Easton of the University of Cambridge said.

Mutations in these genes prevent them from repairing changes in other sections of DNA in breast tissue, raising the risk of further mutation.

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