Frampton weighed in one pound over the featherweight limit, but initially said the fight would go ahead regardless, albeit not exactly as planned.
While that decision had looked set to ensure the fight would go ahead, matters took a weird twist late yesterday evening as 24-year-old Gutierrez reportedly suffered an accident in his Belfast hotel room.
Frampton's failure to make the weight meant that the fight was no longer a WBC title eliminator for him.
If Gutiérrez wins, he will still meet WBC featherweight champion Gary Russell Jr as a mandatory challenger for the belt, but "The Jackal" has voided that opportunity after today's weigh-in.
"I tried everything I could to cut down, but unfortunately, my body just wouldn't allow it in the end".More news: IPL media rights: SC sends BCCI notice on e-acution
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"I've spoken so many times about the atmosphere in the Odyssey Arena, I don't think it can be created anywhere else in the world, and even in bigger stadiums, it just isn't the same". I'm still very much looking forward to returning home tomorrow night in front of the best fans in the world.
McGuigan left Las Vegas feeling deeply frustrated in January after witnessing Frampton dethroned by Mexican rival Leo Santa Cruz, the man from whom he had taken the WBA world featherweight title six months earlier in Brooklyn.
Frampton, also known as "The Jackal" tweeted on Friday: "After a long training camp of intense prparation.I was disappointed that I came in 1lb over the featherweight limit today".
He remains an overwhelming favourite to win.