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Oosthuizen, who finished second in the US Open in 2015 and lost a play-off for the Open a month later, had to settle for a 68 to finish four under par.
In the first round, McIlroy only hit five fairways en route to a 78. You can still make birdies out there.
Joining Matsuyama two shots back is a group that consists of PGA Tour rookie Xander Schauffele (73), amateur Cameron Champ (69), 36-year-old PGA Tour veteran Brandt Snedeker (69) and 21-year-old South Korean Kim Si-woo (70), the youngest player to win the Players Championship.
It was the first time since the rankings system was launched in April 1989 that the world's top three players have all failed to make the third round of a major. I've been there a handful of times and had some good finishes.
"You can not play this golf course if you're not in position off the tee and I wasn't in position", McIlroy said. "I've pictured winning the U.S. Open a lot of times before".
Just about everything already has at Erin Hills.
"The course was just drier", he said. There have been no reports yet of anyone getting sick.
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Brooks Koepka ended Friday's second round of the U.S. Open tied atop the leaderboard at 7 under with three other golfers. It came after he chunked a chip, then putted his long birdie attempt off the green and down a steep slope behind the hole.
One shot back. Jamie Lovemark.
"I couldn't have shot any higher", Johnson said.
"It is always cool to be part of some sort of history in golf, but I'd rather be remembered for something that's done on Sunday", Fowler said.
The U.S. Open is wide open going into the weekend.
But the late birdie spree was not enough to lift McIlroy to safety as the exit door loomed.
Other notable players failing to make the cut included British Open champion Henrik Stenson (147), former Masters winners Charl Schwartzel (147) of South Africa and Australian Adam Scott (147) and double Masters victor Bubba Watson (148). That left only four of the top 12 in the world to play the weekend at Erin Hills.
By the end of the day, that wasn't even the most shocking number.
He also said he might have been rattled by starting out Thursday afternoon knowing that Rickie Fowler had already posted a 65. "We're in a good spot". And I can hit those shots. So that kind of takes the advantage away from the bombers. But he also struggled around the greens, failing to get up and down once in six opportunities.
The stats prove him right.
"I was in the hay too much over the last couple of days", Day told reporters about the knee-high fescue grass lining the fairways at the links-style layout in the Wisconsin countryside.