Ireland's new Taoiseach is not expected to be formally confirmed until 13 June when the Dail parliament resumes.
Although the former minister for social protection is fiscally conservative, many are comparing him to Canadian prime minister Justin Trudeau and new French president Emmanuel Macron because of his progressive politics. If he does win, he will succeed current Taoiseach Enda Kenny and become the youngest as well as the first non-Asian Prime Minister of the country, and one of the youngest to occupy such a high post all across the world.
Vardakar was born iand raised in Dublin to mother Miriam, a nurse originally from Waterfold and father Ashok, a doctor from Mumbai.
"If my election shows anything it's that prejudice has no hold in this Republic", he said.More news: China, EU claim climate leadership as United States steps back
More news: Deadly attacks disrupt Britain ahead of general election
More news: Texas A&M tops Iowa 3-2, reaches final in Houston Regional
Varadkar's election as leader of the governing Fine Gael party on Friday means he will nearly certainly succeed Enda Kenny as prime minister in the coming weeks, marking another symbolic moment for Ireland.
Varadkar said he was "aware of the enormous challenges ahead". Its headline read: "Indian-origin Leo Varadkar to be next Ireland PM".
Opposition MPs were quick to denounce Varadkar's election, with his constituency rival Ruth Coppinger of the left-wing Solidarity party claiming that his campaign had given people a glimpse of the kind of divisive policies Fine Gael would like to pursue.
Although he could be ratified as Taoiseach within weeks, questions already loom over how long Mr Varadkar can hold on to the office. It's just part of who I am, it doesn't define me. "I'm not a half-Indian politician, or a doctor politician or a gay politician for that matter".
"I think everybody needs to follow the words of Simon Coveney - It's all about unifying and getting on with the job, and leading the party and country on to bigger and brighter things".