In his first public comments since the shooting, Dr. Jack Sava of MedStar Washington Hospital Center said it's a "good possibility" that the Louisiana Republican will be able to return to work in his full capacity.
Doctors rushed Mr Scalise to surgery, pumping blood into his body to counteract his multiple haemorrhages.
President Donald Trump sent a video message to the game, highlighting Scalise who remains in critical condition on Thursday after several surgeries.
"I feel a lot more confident and a lot more optimistic than I did two or three days ago".
Salva said he expects Scalise to remain in the hospital for a considerable length of time, presumably weeks, and will need to undergo further operations.
The shooting at a baseball field that critically wounded a Republican congressman and injured several others is forcing lawmakers to ask what more should be done to ensure the safety of themselves and their staff.
Sava declined to put a timeline on when that would happen or when Scalise, 51, would be able to leave the hospital.
The bullet that had hit Scalise was a single rifle round that "travelled across his pelvis, fracturing bones, injuring internal organs, and causing severe bleeding". Griner was in good condition "and in good spirits", Sava said.
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House Speaker Paul Ryan and Minority Leader Nancy Pelosi told CNN's Jake Tapper on "Erin Burnett OutFront" that despite party affiliation they were both on "Team Scalise" on Thursday. A relative said Friday morning that his condition at George Washington University Hospital had been upgraded from critical to serious.
Suffering relatively minor injuries were two Capitol Police officers, David Bailey and Crystal Griner, and House GOP aide Zack Barth.
Sava said Scalise has been sedated throughout his hospital stay but his sedation had been "turned down" enough to see him respond to his family's presence.
Scalise was fielding ground balls at second base Wednesday when he was shot at a practice for an annual Republicans-Democrats baseball game.
Scalise was wounded when a gunman opened fire at a Republican baseball practice in Virginia on Wednesday. His social media contained anti-Trump and anti-Republican posts.
The shooter was identified as James T. Hodgkinson, a 66-year-old home inspector from IL who had several minor run-ins with the law in recent years and belonged to a Facebook group called "Terminate the Republican Party".
More than $1 million has been raised for charity through the Congressional Baseball Game, its host organization announced Thursday, a day after a shooting unfolded at the Republicans' practice for the game. He died later from injuries sustained in a shootout with police. One person who won't be among them: President Trump.
Addressing Scalise, Rep. John Lewis, D-Ga., said, "You are not alone".
Speaking earlier Friday in Miami, Trump said Scalise "took a bullet for all of us" when he was shot.