The Pence team knew what they were getting themselves into when they joined the Trump ticket and team nearly a year ago.
He famously calls himself "a Christian, a conservative, and a Republican, in that order" but in contrast to his wildly exaggerated reputation as a vicious homophobe, he is not doctrinaire.
I don't feel an iota of sympathy for Pence. At the start of the administration, the vice president publicly defended Flynn against allegations that he had discussed sanctions with Russia's ambassador to the US before Trump's inauguration.
Trump's policies have already set in motion damage to the health of women worldwide - and those who think his potential impeachment would undo that are nearly certainly wrong. Even if the myriad scandals and investigations confronting the White House do not sink Trump, and he manages to dodge the potential health risks and assassination threats that any older, unpopular (and likely unhealthy) president faces to serve out a full term or two in office, the relatively unscathed Pence will be there to take the torch. Trump is an unstable and unsafe presence in the Oval Office, and the GOP put him there, defending his actions and enabling his worst instincts.
Initial statements from the White House said Mr Trump had fired Mr Comey on the recommendation of the Justice Department, due to his handling of the FBI investigation into Hillary Clinton's private email server.
The filing comes as Republicans and Democrats are chattering about the possibility - however far-fetched, remote and deep into the future - that Pence could someday ascend to the presidency.
Pence stands for everything the liberal Democrats hate; he is a hard-core conservative who has always been in opposition of abortion rights and has pushed for religious exemption to laws on LGBTQ rights.
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The Comey firing represents a second rough patch for Pence.
"So if anybody's been working together here to clear a perp, it is James Comey and Barack Obama in April and through July of 2016 - and since that is what happened, the Democrats and the media are now projecting on Donald Trump that which they did", Limbaugh said. He spoke to the US Chamber of Commerce as well on Thursday in Washington.
"There's no mystery why we are here today. It's been one of the easiest thing to predict".
On his show Tuesday, Limbaugh said there is "an ongoing effort to sabotage Trump personally, politically, professionally".
"And this sabotage is occurring from within the government and perhaps even from within the Trump administration". Given his prominence in an increasingly unpopular administration, says Joel K. Goldstein, a law professor at Saint Louis University and an expert on the vice presidency, "it is very possible that Pence's chances of being elected president may have been greater as a defeated vice presidential candidate than as a successful one".
It is the steadying, practical role that Republicans had hoped Pence would play for a president who has no political or legislative experience and is openly disdainful of the details of policy.
Actually, the subhead says it all: Trump is insane.