Soundgarden was the scheduled headliner for Pointfest on Saturday in Maryland Heights, Missouri.
Frontman Kurt Cobain of Nirvana, who towered over the grunge scene, killed himself in 1994 and Stone Temple Pilots singer Scott Weiland died on a tour bus in 2015 from a drug overdose.
A full autopsy report was not yet completed Thursday afternoon.
It is believed Cornell died within an hour of leaving the venue. TMZ has confirmed with police that a family friend had to force his way into Cornell's hotel room, where he then found him with a band around his neck. "He seemed to be genuinely excited to be performing in Detroit", the concertgoer said.
"It is being investigated as a possible suicide". She expects some information to be released about the results later in the day. "It takes on a life of its own, and when you listen to it, it becomes your song".
Billboard described Cornell as being in "fine form and spirits" during Soundgarden's show last night.
Cornell was one of the founding members of Soundgarden in 1984, and was the lead singer until 1997 when the band announced it was breaking up. He added that more details would be released in a statement later Thursday.
Cornell died at the MGM Grand Detroit hotel, Woody said. "He was found on the bathroom floor, our medical unit were called and he was pronounced dead on scene", a spokesperson said.More news: Sen. John Cornyn among candidates to be Federal Bureau of Investigation director
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Cornell had been on tour in Detroit at the time of his death.
Kiss singer Paul Stanley tweeted he was "Stunned to hear the death of Chris Cornell", while Aerosmith's Joe Perry called his passing "a sad loss of a great talent to the world".
"His wife Vicky and family were shocked to learn of his sudden and unexpected passing, and they will be working closely with the medical examiner to determine the cause", Brian Bumbery, Cornell's representative, says in a statement. The station played non-stop songs from Soundgarden, Cornell's other bands and his solo work, as well as artists who covered Cornell's material and those who were influenced by him.
Cornell had just performed a concert with Soundgarden at the Fox Theater in Detroit.
"A tweet on the star's official Twitter reads: "#Detroit finally back to Rock City!
Soundgarden reunited in 2010 and embarked on the current USA tour in April.
Cornell also toured previous year with his group Temple of the Dog, which consisted of members both Soundgarden and Pearl Jam.
The Soundgarden and Audioslave star - who co-wrote and performed "You Know My Name", the theme tune to Daniel's first ever James Bond movie "Casino Royale" - was only 52 when he was found dead and now Daniel has paid tribute to the late musician.