Both teams are level on points.
Real Madrid will be up against Celta Vigo on Wednesday who were knocked out of the Europa League semifinals by Manchester United last week. He has scored 21 goals in 29 games against local rivals Atletico Madrid, 20 goals in 12 games against Getafe and 16 goals in 16 games against Barcelona.
Zinedine Zidane is done rotating his squad and will use Ronaldo and the rest of the regular starters when Madrid plays at Celta Vigo with a chance to regain the Spanish league lead and move into position to clinch its first title in five years. "It's what has taken us this far".
Real Madrid also fulfilled their part of the bargain with a 4-1 win at home to Sevilla.
The 32-year-old's tap-in from six yards was one of the easier of his goals but his second - a strike from a tricky angle just inside the box - matched the occasion. Deportivo La Coruna also guaranteed a place in the top flight after a 0-0 draw at Villarreal.
Sporting will join Granada and basement club Osasuna, who were relegated last month, in the Segunda Division.
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Not long after, Toni Kroos added to the score-line by expertly slotting Nacho's low cross past Sergio Rico.
Nacho made sure that the edgy atmosphere inside the Bernabeu never arrived with this bit of quick thinking. "I expect Celta to play like normal".
Three minutes later, Real doubled their lead as Ronaldo slotted home from close range after James Rodriguez's shot was parried into the Portuguese's path. Sevilla were on the back foot for most of the half but they almost pulled a goal back in the 32nd minute when Jovetic's lob crashed against the crossbar.
Barcelona is trying to win the league title for the third straight time.
Barcelona cruised to victory over Las Palmas to stay in front, and now it starts hoping for a Madrid setback.
Sevilla responded to falling behind by hitting the post, Stevan Jovetic's effort crashing back off the frame of the goal before Real doubled their lead on 23 minutes.