Goals from Victory Wanyama and Harry Kane saw Tottenham earn a 2-1 victory at White Hart Lane on Sunday to end United's hopes of finishing in the top four this season.
It means that the only chance United have of making Europe's elite competition next season will be through winning the Europa League, the final of which they will contest against Ajax next week.
"I don't think [Pogba will be available]".
Jose Mourinho believes Manchester United's Premier League rivals would rather be in the Europa League final than scrapping over a top-four finish.
"I am happy, I am fine with what we had in terms of individual performances. There were no injuries, and [now there is] one less match to play because in this moment, the Premier League for us, it is just matches we don't want to play".
With Europa League commitments in mind, Mourinho has made it clear he will rotate his playing squad for Wednesday's game against Southampton - and the final day clash against Crystal Palace.
This adds huge significance to the Europa League final against Ajax later this month.
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"With two matches in hand that we had to play later, it is impossible".
"Other clubs fighting for the top four would like to be in our position".
Jose Mourinho insists Manchester United will continue to fight for titles instead of clambering to make the top four this season.
Man Utd goalkeeper David De Gea could reportedly be denied the opportunity to play in the last Premier League game of the season at Old Trafford. I can not lose 5-0 or 6-0. After 2-0 we brought a bit more balance to the team because we put players in the right positions and we put midfielders in midfield and the team improved a lot.
"Two bad goals conceded, but it's a positive game for us".
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"The players who needed the rest got the rest".