A man who appeared intoxicated drove his auto the wrong way up a Times Square street Thursday and plowed into pedestrians on the sidewalk, killing one and injuring 22 others, authorities and witnesses said.
Mayor Bill de Blasio and O'Neill reassured the public that the incident was not terror-related.
New York Fire Commissioner Daniel Nigro said four people were critically injured but were expected to survive.
Police said 23 people were hit by the vehicle, including an 18-year-old woman who died.
NEW YORK (AP) - A Times Square motorist accused of steering his auto onto one of the busiest sidewalks in the USA and mowing down pedestrians has been charged with murder and 20 counts of attempted murder, police say.
Rojas, 26, is a Bronx resident, USA citizen and Navy veteran, the mayor said.
In one of his two previous DWI arrests, the suspect was driving faster than 99 miles per hour in a 50 miles per hour zone, sources familiar with his record say.
According to the Associated Press, the suspect initially tested negative for alcohol, but other tests would be run to determine if he was high.
First responders are assisting injured pedestrians after a vehicle struck pedestrians on a sidewalk in Times Square in NY, U.S., May 18, 2017. He was combative with officers who handcuffed him, authorities said.
One woman is dead and more than 20 injured after a speeding vehicle ploughed into pedestrians in New York's Times square.More news: Tom Brady Inks Endorsement Deal With Ashton Martin
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The incident took place close to noon ET (1600 GMT) on a bright, sunny day.
A tourist from Argentina told CNN affiliate WABC that he was shocked to see the vehicle that "was like bowling, hitting people".
Initial reports of the incident revived memories of July past year when a man driving a truck killed at least 84 people, 10 of them children, and injured 202 in the French city of Nice.
Police are ruling out terrorism and the driver is said to have a history of drink driving.
Rojas is now being transported to a facility where he will undergo testing for drugs and alcohol.
Witnesses in Times Square watched in horror as vehicle plowed over pedestrians, killing one and injuring 19 others. Rojas was charged with misdemeanor battery and resisting an officer without violence, but it was unclear how the case was resolved.
"This is a tough day for New York City, but I want to thank our first responders who got here so quickly". But do you think that, if the suspect said, "Allah made me do it!" this story would have been covered differently no matter what drugs he was on?
He said he saw about five people who looked gravely injured - "people, really bad, in front of us".
"My heart goes out to the family who lost a loved one and those injured in Times Square crash", Rep. Carolyn Maloney, D-NY, said on Twitter. Press secretary Sean Spicer tweeted that Trump was briefed before NY authorities confirmed the death.
Other witnesses said the vehicle drove against traffic and onto the pavement before striking the pedestrians at about midday local time.