The Interior Ministry is responsible for securing France amid a high threat of extremist violence. He backed Macron earlier this year.
The list name, which included 18 ministers and four junior ministers, contained several female faces, a move with which the country's new top official wants to deliver on gender parity promise he had campaigned for.
French newspapers saw the choice of Philippe as PM and the handing of important economic portfolios to rightwingers Bruno Le Maire and Gerald Darmanin as a clear indication of Macron's priorities.
Le Drian's weakness could be his links to the unpopular Hollande.
Germany's foreign minister quickly welcomed Le Drian, describing him as someone of "enormous political experience and great renown".
Philippe and Macron chose experienced politicians from the left, the center and the right for the main positions.
"A minister doesn't set conditions for a president or a prime minister", he told reporters, adding that Hulot will have to stick to Macron's program.
In the list appeared Sylvie Goulard, a centrist European Union lawmaker, in charge of defense affairs, Agnes Buzyn, solidarity and health minister and Muriel Penicaud, a minister in charge of employment issue.More news: Here's your first look at young Sheldon's 'Big Bang Theory' spinoff
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Members of civil society without government work on their resumes were appointed to some ministerial posts.
Nicolas Hulot is a prominent environmental campaigner and documentary journalist whose television series promotes environmentalism while showing off lovely landscapes. Macron named a mix of prominent and un. The 48-year-old served as agriculture minister from 2009 to 2012 under former President Nicolas Sarkozy.
The government appointments are part of a delicate balancing act that Macron has to perform ahead of the mid-June legislative elections.
France' s new President will hope his team delivers a majority in the parliamentary elections in June.
French President Emmanuel Macron has delivered on his promise to achieve gender parity in government by appointing an equal number of men and women to his cabinet.
They arrived for their first meeting Thursday with smiles, posing for photographs on the front porch of the presidential Elysee Palace in Paris.
He supervised French military operations in Mali, Central African Republic, Iraq and Syria.
More than 20 of the country's leading media outlets, including Le Monde, Agence France-Presse, Le Figaro, and TF1 signed an open letter to the new president after his office had invited particular journalists to cover his first official trip outside Europe.