Fire Chaplain Danny Ringer told reporters at the scene that one person was known to have been killed due to the twister.
Elk City Police Chief Eddie Holland estimated the storm severely damaged more than 75 homes.
National Weather Service Meteorologist Mike Umscheid says radar images suggest the storm may have produced other brief, rain-wrapped tornadoes as it moved over rural farmland.
Strong winds caused a small plane to flip over at Eppley Airport in Omaha, Nebraska, Tuesday, NWS reports.
In northwest Wisconsin, one person was killed and 25 were injured when a reported tornado hit a mobile home park, Barron County Sheriff Chris Fitzgerald said.
By evening, the National Weather Service listed almost 20 reports of tornadoes from Texas, Oklahoma, Kansas, Nebraska and Wisconsin, although some of those could be multiple reports of the same tornado.
The tornado, which ripped through around 5:30 p.m., destroyed about 50 mobile homes - 10 of which are standing but inhabitable - and injured 25 people, 17 of whom were taken to hospitals.
Emergency crews are assessing the damage, but Fitzgerald estimates the damages to be in the millions.More news: Trump told Russians that firing 'nut job' Comey eased pressure from investigation
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Authorities say at least 40 homes were destroyed.
Police are encouraging displaced residents to seek shelter at the city's First Baptist Church.
Mikles was killed after he chose to leave his mobile home in a pickup to seek shelter in the area about a mile north of State Highway 152 and just east of Merritt Road in a rural area.
The storms hit late in the afternoon Tuesday and into the evening, leveling the Prairie Lake Estate Mobile Park near Chetek, Wisconsin, about 110 miles (177 kilometers) northeast of Minneapolis.
Meanwhile, Wis. Gov. Scott Walker declared a state of emergency for three counties in northwestern part of the state following a deadly tornado and damaging storms.
Home after home was gutted by intense winds, tree tops were stripped clean and memories were spread out all over the ground of the Prairie Lake Estates mobile home park. Cattle have been killed, but he says he has no immediate reports of human injuries. Helicopter video from WCCO-TV and KARE-TV shows extensive damage at the trailer park, with several homes reduced to rubble.
Scattered tornadoes have been reported in the nation's midsection.