Social media ridiculed the apparent error, with the hashtag #covfefe trending worldwide on Twitter.
Griffin, who helped with CNN's New Year's Eve coverage, has apologized, saying that the brief video was "too disturbing" and wasn't amusing. According to Twitter Audit Report, a website that analyzes how many of an account's followers are real people, just under half of those aren't real: 15.9 million are authentic, and 15 million aren't, for a 51% reality rate.
"Despite the negative press covfefe", Trump wrote, and nothing more.
The tweet immediately went viral and became one of the president's more popular posts before it was taken down after almost six hours online.More news: Arsene Wenger's future at Arsenal set to be revealed on Wednesday
More news: Indian Navy's Eastern Fleet ships put at highest alert
More news: Amber Alert issed in Salem, MO teen's abduction
Donald Trump's latest Twitter salvo was perhaps his most confusing to date.
He poked fun at the typo himself, tweeting around 6am: "Who can figure out the true meaning of "covfefe"???" Dozens of definitions have been submitted the Urban Dictionary website, which crowdsources meanings for slang terms.
In mid-December, Mr Trump tweeted "unpresidented" instead of "unprecedented".
The White House says they have a system in place to capture and preserve all tweets, even ones which have been deleted.